Ozempic is changing the way people lose weight, but is it also weakening their bones?
As a registered dietitian nutritionist (RDN), I’ve noticed more patients on Ozempic are being diagnosed with osteopenia, a condition that leads to lower bone density and a higher risk of fractures. With the rising popularity of semaglutide (Ozempic) for weight loss and diabetes management, it’s crucial to understand its potential impact on bone health.
Recent research suggests that GLP-1 receptor agonists like Ozempic may contribute to bone density loss, especially when paired with rapid weight loss and nutrient deficiencies. If you’re using or considering this medication, it’s important to be proactive about protecting your bones.
In this article, we’ll break down the connection between Ozempic and bone health, explore the risks, and share practical strategies to help you maintain strong bones while achieving your weight loss goals.
How Ozempic May Impact Bone Health
Emerging research suggests that semaglutide may contribute to bone density loss. While weight loss itself can reduce BMD, the exact ways in which Ozempic influences bone health are still being studied.
Potential factors that may contribute to bone loss while taking Ozempic include:
- Rapid Weight Loss: Losing weight too quickly can reduce both fat and lean muscle mass, which play key roles in bone strength.
- Changes in Bone Remodeling: Some studies suggest that GLP-1 medications may alter the natural process of bone breakdown and rebuilding.
- Low-Calorie Diets: Many people on Ozempic eat significantly less, sometimes to the point of nutrient deficiency. A diet lacking calcium, vitamin D, and protein can accelerate bone loss.
Ozempic Side Effects: Weight Loss Benefits vs. Bone Health Risks
Weight loss with GLP-1 medications can bring major health benefits:
- Improved blood sugar control
- Reduced risk of heart disease
- Less strain on joints and improved mobility
However, rapid weight loss and potential declines in BMD raise concerns, especially for older adults or those at risk for osteoporosis. Fragility fractures, such as hip fractures, can have serious consequences, leading to long-term disability or even increased mortality risk.
If you’re taking Ozempic, it’s essential to weigh these factors and take proactive steps to protect bone health.
Balancing the benefits of weight loss with the potential skeletal risks is essential. Individuals, particularly those over 50 or with existing risk factors for osteoporosis, should work closely with their healthcare providers to develop a comprehensive plan that prioritizes both metabolic health and bone integrity.
Best Test To Assess Bone Density
Before starting Ozempic (or any GLP-1 medication), it’s a good idea to check your bone health. A DEXA scan (Dual-Energy X-ray Absorptiometry) is the best test for measuring bone mineral density. This simple scan can help detect early signs of osteopenia or osteoporosis, allowing for early intervention.
It’s also a good idea to check your vitamin D and calcium levels which are key nutrients that support bone health. If your levels are low, your healthcare provider or a registered dietitian nutritionist can guide you on the right supplementation based on your levels.
Vitamin D & Calcium’s Role in Bone Health

Adequate levels of vitamin D and calcium are essential for maintaining strong bones. A simple blood test can determine if supplementation is necessary before starting weight loss medications like Ozempic.
Protecting Your Bones While Using Ozempic
If you’re on Ozempic (or considering it), here are some ways to protect your bones:
- Stay Active with Weight-Bearing Exercise: Activities like resistance training and strength exercises help maintain bone density.
- Optimize Your Nutrition: Get enough calcium and vitamin D from foods and fortified products.
- Avoid Extreme Calorie Restriction: Eating too little can deprive your bones of essential nutrients. Aim for a balanced diet rich in protein, vitamins, and minerals.
- Monitor Bone Health: Periodic DEXA scans can track any changes in bone density and help guide treatment decisions.
- Supplement If Needed: If blood tests show deficiencies, your provider may recommend calcium and vitamin D supplements.
- Talk to Your Doctor: If you have a history of osteoporosis or are at higher risk for fractures, discuss alternative treatments or preventive strategies.
Keep In Mind
Ozempic is a powerful tool for weight loss and diabetes management, but it’s important to be mindful of its impact on bone health. By taking proactive steps, like maintaining a nutrient-rich diet, engaging in weight-bearing exercise, and getting regular bone density scans, you can reduce your risk of osteopenia and osteoporosis.
If you’re currently on Ozempic or considering it, talk to your healthcare provider about your bone health to ensure a holistic, personalized approach to your overall health and well-being.
Protect Your Health While Losing Weight with Expert Nutrition Support
Taking Ozempic or another weight loss medication? At Core Nutrition Health and Wellness, we provide personalized nutrition guidance to help you prevent muscle loss, avoid nutrient deficiencies, manage GI issues, and support bone health, so you can achieve sustainable weight loss safely.
Book a consultation with our nutritionist for weight loss to create a plan that optimizes your weight loss and supports bone health.